Prescription Drugs Misuse and Addiction

Types of Commonly Misused Prescription Drugs

While prescription drugs are intended to support health, certain types are more prone to misuse and addiction due to their effects on the body and mind. 

Opioids

Opioids are powerful pain relievers, such as oxycodone, hydrocodone, morphine, and fentanyl. They are typically prescribed to manage severe pain, especially after surgery or for chronic pain conditions like cancer. When used as directed, opioids can provide relief by blocking pain signals to the brain.

Opioids affect the brain’s reward system, causing euphoria—factoring into their potential for misuse¹. When misused—either by taking higher doses, using them more frequently, or combining them with other substances—opioid use can lead to dangerous consequences. Tolerance builds, meaning users may need more of the drug to achieve the same effect, leading to a cycle that ends in addiction. Opioid use also increases the risk of overdose, which can be fatal², necessitating detoxing with professional medical care.

Benzodiazepines

Benzodiazepines, or “benzos,” are a type of sedative prescribed for anxiety, panic disorders, and sleep disorders. Medications like diazepam, alprazolam, and lorazepam calm the nervous system³, providing short-term anxiety and stress relief.

Similar to opioid misuse, benzodiazepine misuse can quickly lead to tolerance and dependence by increasing dopamine and GABA neurotransmitter release⁴, triggering the brain’s reward system. Long-term use may cause memory impairment, mood swings, and coordination issues. 

Benzodiazepine detox requires tapering and medical care, as abrupt cessation is extremely dangerous.

Stimulants

Stimulants, including medications like amphetamines (Adderall) and methylphenidate, are prescribed for attention-deficit hyperactivity disorder (ADHD) and certain sleep disorders like narcolepsy. These drugs enhance the release of dopamine, which can improve focus and concentration⁵.

When misused, someone may take higher doses of stimulants to increase energy and focus—which is commonly seen in academic or high-stress environments in an attempt to enhance performance. 

However, stimulant misuse can lead to serious side effects, such as increased heart rate, high blood pressure, paranoia, and even psychosis⁵. Over time, misuse may also result in dependency, as the brain relies on the increased dopamine levels for motivation and focus.

How Do People Misuse Prescription Drugs?

Taking medication differently from how it was prescribed leads to misuse:

• Taking Higher Doses: Someone may take more than the recommended dose for enhanced effects, like stronger pain relief or a more intense sedative or stimulant effect. 
• Using Them More Frequently Than Prescribed: Even if the dose is correct, taking medication more often than prescribed can lead to tolerance and dependence. For example, unnecessarily taking a pain reliever can reduce its effectiveness over time, leading to a cycle where the person feels they need even more of the drug.
• Taking Someone Else’s Prescription: Prescription drugs are tailored to individual health needs, so using someone else’s medication can be risky. A medication that helps one person might have dangerous side effects for another.
• Ingesting Them Differently Than Prescribed: To enhance drug effects, people may snort or inject prescription drugs to enter the bloodstream quickly. This behavior heightens the risk of addiction, overdoses, and severe physical damage, such as respiratory problems or infections.
• Combining Them With Other Substances: Mixing prescription drugs with alcohol, over-the-counter medications, or illicit drugs can amplify side effects and lead to dangerous reactions. For example, someone may combine benzodiazepines with alcohol for a stronger effect; however, this severely slows the respiratory system, increasing the chance of negative health effects. Refer to your doctor for what you should avoid when taking prescription drugs.

All of these practices increase the risk of overdose, addiction, and adverse health effects. Taking medication strictly as prescribed and staying informed about its effects can help avoid these adverse reactions.

Signs and Symptoms of Misuse and Addiction

Wellness Resource Center describes the physical symptoms⁶ of those misusing sedatives like opioids or benzodiazepines, including drowsiness, confusion, or slowed breathing. For stimulant misuse, symptoms look like increased energy, rapid speech, reduced appetite, dilated pupils, and heightened blood pressure. 

Behavioral changes can be equally telling, including erratic behavior, social withdrawal, or unexplained financial troubles as the person attempts to obtain more medication. Drug use and addiction significantly impact an individual’s emotional and psychological state, causing heightened anxiety, irritability, mood swings, or depression. 

Addicted individuals may prioritize obtaining and using the drug over their responsibilities, relationships, and personal well-being. Developing a tolerance, needing increasingly higher doses to achieve the desired effect, and experiencing withdrawal symptoms like nausea or agitation also signal dependence. 

Prescription Drugs Misuse and Addiction Statistics

Prescription drug misuse is a significant concern in the United States. In 2021, approximately 14.3 million individuals ages 12+ reported misusing prescription psychotherapeutic drugs⁷ within the past year. Breaking this down, about 8.7 million people misused prescription pain relievers, 4.9 million misused tranquilizers or sedatives, and 3.7 million misused stimulants. Additionally, an estimated 5 million individuals had a prescription opioid use disorder during the same period. 

Alarmingly, there were approximately 16,706 overdose deaths involving prescription opioids, underscoring the critical need for effective prevention and treatment strategies.

Why Do People Get Addicted to Prescription Drugs?

Addiction is complex—while these medications are often prescribed with the best intentions, their misuse can lead to physical dependence and addiction. This happens not only because of their chemical effects on the brain but also due to psychological, societal, and environmental factors. 

Psychological Factors

Mental health disorders, such as anxiety, depression, and trauma, can be significant risk factors for prescription drug addiction. People struggling with mental health challenges may turn to prescription drugs as a form of self-medication to alleviate their emotional pain or manage symptoms. 

For example, someone with anxiety may misuse benzodiazepines to feel calmer, while a person with chronic depression might misuse stimulants for a temporary sense of energy or motivation. Over time, this reliance can create a cycle of misuse, tolerance, and dependence as the underlying mental health condition remains untreated.

Societal Influences

Societal pressures can play a powerful role in prescription drug addiction. Peer pressure could encourage the misuse of stimulants like Adderall to enhance academic performance or opioids to achieve a euphoric effect. 

Social media and film can further glamorize prescription drug misuse by showcasing it as a trend or coping mechanism. These societal influences can make it difficult to resist experimenting with prescription drugs, even when they understand the potential dangers.

Accessibility and Availability of Prescriptions

Many people have unused medications in their homes, making it easier for others to obtain them without a prescription. Also, healthcare systems sometimes overprescribe certain medications, such as opioids or benzodiazepines, which can unintentionally create opportunities for misuse. So, easy access lowers the barriers for initial experimentation and increases the likelihood of repeated use.

Misunderstanding of the Risks Associated with These Medications

Often, people assume that medications prescribed by a doctor are inherently safe, even when taken in ways not intended. This can lead to downplaying the risks of increasing their dosage, sharing medications, or using them for recreational purposes. 

Treatment Options for Prescription Drug Addiction

Recovering from prescription drug addiction requires a well-rounded approach that addresses both physical and emotional challenges. Medical detox is often the first step, helping patients safely manage withdrawal symptoms under professional supervision. While detox is essential, it’s only the beginning, as lasting recovery requires addressing the root causes of addiction.

Medication-assisted treatment (MAT) is particularly effective for opioid or benzodiazepine addiction⁸, using medications like buprenorphine or naltrexone to ease cravings and withdrawal symptoms. When combined with counseling, MAT helps individuals focus on rebuilding their lives. Therapists play a key role in offering tools like cognitive behavioral therapy (CBT) to identify harmful patterns and develop healthier coping strategies.

For those with co-occurring mental health issues, dual diagnosis treatment is essential, addressing addiction and mental health conditions simultaneously to reduce relapse risk and improve overall well-being. Support groups like Narcotics Anonymous (NA) or SMART Recovery also provide community and accountability, offering encouragement from others with shared experiences. 

Preventing Prescription Drug Misuse

Preventing addiction requires proactive measures—from yourself, healthcare providers, and communities. Patient education from healthcare providers can explain proper medication use, risks of misuse, and the importance of not sharing prescriptions. Safe prescribing practices, such as using prescription drug monitoring programs and prescribing the lowest effective dose, can also reduce misuse.

At home, secure storage and proper disposal of medications help prevent unauthorized access. You can look up your local community take-back programs to find a safe way to dispose of unused drugs. 

Especially for influential adolescents and young adults, awareness campaigns in schools and communities can educate about the risks of misuse. And encouraging open communication in the family and peer groups can support responsible medication use, creating a strong foundation for prevention. Together, these measures create a comprehensive approach to reducing prescription drug abuse before it begins.

Find Treatment for Prescription Drug Misuse

View treatment centers for prescription drug misuse in your area to see reviews, methods of care, and accepted insurances.