Xanax (alprazolam) is a widely prescribed medication for managing anxiety and panic disorders. It works by calming the brain and nervous system, providing relief from overwhelming fear, tension, and restlessness. While it’s effective in reducing symptoms of anxiety, it also carries significant risks, including addiction. Here’s what you need to know about how Xanax works, its uses, and the potential consequences of both short- and long-term use.
To understand what Xanax does and why it’s effective, it helps to know how it interacts with your brain to ease anxiety and panic symptoms.
Xanax is part of a class of medications called benzodiazepines that work by enhancing the effects of gamma-aminobutyric acid (GABA), a naturally occurring chemical messenger in your brain. Think of GABA as your brain’s natural calming system: It helps regulate brain activity by reducing excitability in the nervous system. When you take Xanax, it amplifies this natural calming effect, which is especially helpful when anxiety or panic has kicked your brain into overdrive. Essentially, Xanax increases the effects of GABA1 to turn down the volume on excessive brain activity, making it easier to feel relaxed and in control.
One reason Xanax is often prescribed for anxiety and panic disorders is its rapid onset of action. Most people start to feel its calming effects within 30-60 minutes of taking the medication. During this time, Xanax works to reduce common anxiety symptoms:2
The quick-acting nature of Xanax makes it helpful for managing acute anxiety episodes or panic attacks, where the person experiencing symptoms needs rapid relief.
Most people take Xanax for anxiety or panic disorders, though it has occasional off-label applications.
Xanax is most commonly prescribed for generalized anxiety disorder (GAD),3 a condition marked by more than just occasional stress or nervousness. People with GAD feel persistent worry that’s hard for them to control, which is often accompanied by physical symptoms like fatigue, irritability, and muscle tension that can significantly impact daily life. By working with the brain’s natural calming system, Xanax can provide relief from both the emotional overwhelm and physical discomfort of anxiety.
For people living with panic disorder, Xanax can be a key part of their treatment plan. Panic attacks often strike without warning, triggering intense physical and emotional symptoms4 that can feel terrifying:
During these episodes, Xanax’s quick-acting properties can help break the cycle of panic, allowing the person to regain their sense of control.
Healthcare providers sometimes prescribe Xanax for conditions beyond its FDA-approved uses, a practice known as “off-label” prescribing. These might include:
Off-label use should always happen under close medical supervision, with clear communication about benefits and risks.
You should always use high addiction-risk medications like Xanax with careful guidance from a qualified medical professional. To learn more about who can prescribe benzos and what to look for in a provider, see our article on clinical staff qualifications.
A closer look at Xanax’s effects—including the short-term benefits and the potential long-term changes that can occur with extended use—helps us understand how it affects the body and mind.
When you take Xanax, you’ll likely notice its effects within an hour. Most people experience:
While these effects can provide welcome relief from anxiety symptoms, they can also affect your ability to perform certain tasks. Do not drive or operate machinery until you understand how Xanax affects you personally. Some people also notice temporary changes in appetite or mild dizziness as their body adjusts to the medication.
Using Xanax over an extended period can change how your body and brain respond to the medication:
Tolerance often develops first. This means your body gets used to the current dose and starts to need higher amounts to achieve the same calming effect. While this is a normal biological response, it’s important to discuss any changes in the medication’s effectiveness with your prescribing doctor rather than adjusting the dose yourself.
Physical dependence can develop even when you’re taking Xanax exactly as prescribed. This doesn’t necessarily mean you’re addicted; it simply means your body has adapted to the presence of the medication. However, this physical dependence does mean you’ll need medical supervision to safely stop taking Xanax when the time comes.
Some people notice subtle changes in their memory or concentration with long-term benzodiazepine use. One scientific review of 13 studies on the cognitive effects of benzodiazepine use5 found that “long-term benzodiazepine users were consistently more impaired” than people who didn’t take benzos. These effects often improve over time, after reducing or discontinuing use under medical guidance.
While benzos provide relief that some people find very helpful in acute situations, understanding the risks of Xanax use—including side effects and the potential for dependence—helps to ensure you’re using it as safely as possible.
The calming properties that make this medication effective for anxiety are also what make Xanax habit-forming.6 As your brain adapts to taking Xanax regularly, physical dependence sets in. Here’s what that looks like:
One woman in recovery, Grace, talks about her struggle to quit taking Xanax7 after realizing she had become addicted:
It’s honestly miserable. It’s definitely a mind game because I want nothing to do with this, yet in order to function and in order to get off of it I have to keep taking it.
Grace’s Xanax use started as many others’ have: with a standard prescription from her doctor. But Grace’s doctor didn’t sufficiently warn her about its risks. Unfortunately, Grace’s story is not uncommon. Many medical professionals don’t receive adequate training in addiction—which is why it’s important to educate yourself on the true ins and outs of benzos.
If you start to feel you can’t cope with stress or anxiety without Xanax, this could also be a sign that psychological dependence is taking hold. That’s why it’s essential to combine medication with other anxiety management strategies, like therapy and lifestyle changes.
Like all medications, Xanax can cause side effects that range from mild to more serious. Most common Xanax side effects are temporary and usually lessen as your body adjusts.
Common side effects tend to be mild and manageable. You might notice:
While these effects are usually not cause for concern, keeping track of how you feel and sharing this information with your prescribing doctor helps them adjust your treatment plan if needed.
More serious side effects require immediate medical attention. Watch for:
The risk of serious side effects increases significantly when you combine Xanax with alcohol or other sedating medications. That’s why it’s important to tell your healthcare provider about all substances you use, including over-the-counter medications and supplements.
Getting the most benefit from Xanax while minimizing risks requires careful attention to how you use it.
Start with the lowest effective dose. This gives your healthcare provider room to adjust your dose as needed while minimizing side effects. Take the medication exactly as prescribed, even if you’re tempted to take an extra dose during extra-stressful times.
Attend all follow-up appointments with your healthcare provider. These check-ins are important for monitoring how well the medication is working and addressing any concerns early on in the process. Be honest about any side effects or changes you notice—this helps your provider to accurately guide your treatment plan.
Never share your prescription with others, even if they have similar symptoms. Xanax affects everyone differently, and what works for you could be dangerous for someone else.
Some situations make Xanax use particularly risky:
Pregnancy and breastfeeding require special consideration—Xanax can affect fetal development and pass through breast milk. Always discuss family planning with your healthcare provider.
Mixing Xanax with alcohol significantly increases the risk of dangerous side effects. Even small amounts of alcohol can intensify Xanax’s effects on your nervous system.
If you have a history of substance use disorders, you might be at higher risk of developing patterns of problematic use. If this is the case, you may need to explore alternative treatments for anxiety.
Never stop taking Xanax abruptly, as this can cause withdrawal symptoms that range from uncomfortable to dangerous:
The key to safely discontinuing Xanax is working closely with a qualified medical professional who can create and oversee a personalized tapering plan. This typically involves:
If you find yourself struggling with Xanax use, a range of treatment options are available:
While Xanax can be helpful for severe anxiety in the short-term, longer-term use can lead to addiction. If you’re struggling to quit Xanax, there are plenty of options available to detox safely and learn alternative strategies for managing anxiety. Search for a benzo addiction treatment center to start your journey to a healthy, Xanax-free life.
Medical professionals do not recommend using Xanax long-term because of its risks of tolerance, dependence, and cognitive impairments. It’s safer to use Xanax short-term under medical supervision.
If you miss a dose of Xanax, don’t double up on doses to make up for the missed one. Contact your prescribing doctor to learn how to manage this situation in accordance with your treatment plan.
Signs of Xanax misuse include:
Khalifa, Samah A., and Eda M. A. Alshailabi. “BIOCHEMICAL INVESTIGATIONSOF THE EFFECT OF XANAX ON THE CEREBELLAR TISSUES OF MALE MICE.” EPH - International Journal of Applied Science, vol. 7, no. 4, Dec. 2021, pp. 16–20. eijas.com, https://doi.org/10.53555/eijas.v7i4.42.
Anxiety Disorders and Panic Attacks | University Health Service. https://uhs.umich.edu/anxietypanic. Accessed 27 Jan. 2025.
Generalized Anxiety Disorder: When Worry Gets Out of Control - National Institute of Mental Health (NIMH). https://www.nimh.nih.gov/health/publications/generalized-anxiety-disorder-gad. Accessed 27 Jan. 2025.
Ehlers, Anke. “Somatic Symptoms and Panic Attacks: A Retrospective Study of Learning Experiences.” Behaviour Research and Therapy, vol. 31, no. 3, Mar. 1993, pp. 269–78. ScienceDirect, https://doi.org/10.1016/0005-7967(93)90025-P.
Barker, Melinda J., et al. “Cognitive Effects of Long-Term Benzodiazepine Use.” CNS Drugs, vol. 18, no. 1, Jan. 2004, pp. 37–48. Springer Link, https://doi.org/10.2165/00023210-200418010-00004.
Ait-Daoud N, Hamby AS, Sharma S, Blevins D. A Review of Alprazolam Use, Misuse, and Withdrawal. J Addict Med. 2018 Jan/Feb;12(1):4-10. doi: 10.1097/ADM.0000000000000350. PMID: 28777203; PMCID: PMC5846112.
"60 Minutes+ looks at growing problem of "benzo" addiction in the U.S." CBS News. YouTube. https://www.youtube.com/watch?v=iX1SZSAlaBA. Accessed 27 Jan. 2025.
Chouinard, Guy, et al. “New Concepts in Benzodiazepine Therapy: Rebound Anxiety and New Indications for the More Potent Benzodiazepines.” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 7, no. 4, Jan. 1983, pp. 669–73. ScienceDirect, https://doi.org/10.1016/0278-5846(83)90043-X.
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