


Stacy Mosel is a licensed social worker, psychotherapist, and substance abuse specialist. After receiving a Bachelor's degree in Music from the State University of New York at Stony Brook, she continued her studies at New York University, earning a Master's of Social Work degree in 2002.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.




Stacy Mosel is a licensed social worker, psychotherapist, and substance abuse specialist. After receiving a Bachelor's degree in Music from the State University of New York at Stony Brook, she continued her studies at New York University, earning a Master's of Social Work degree in 2002.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.
Kratom is a naturally occurring herbal substance that produces effects similar to those of stimulants (amphetamines, cocaine) and opioids (heroin, morphine).1
While there isn’t enough evidence to state that “Kratom is addictive and can result in a substance use disorder (SUD),” misusing Kratom can lead to physical dependence and potentially dangerous health effects.1
Kratom use can be risky because the effects are largely unknown. Kratom may contain unlisted additives and can have mild to severe adverse consequences.1 As a result, the United States and international agencies have concerns about Kratom.1
If you use Kratom, or you know someone who does, this article will help you understand what Kratom is, Kratom effects, signs of Kratom misuse, and how to seek help if you’re struggling with Kratom misuse or opioid use disorder
Kratom is a substance made from the leaves of a tropical tree known as Mitragyna speciosa that is native to Southeast Asia.1,2 Its leaves can be chewed or dried to be swallowed or brewed into teas and are often labeled as “herbal supplements” and sold over the counter.1,2
Kratom is a popular substance because it can produce euphoric effects similar to stimulants and the pain-relieving effects of opioids. Kratom is believed to act on the mu-opioid receptors in the brain, producing partial opioid-like effects at high doses.
When taken at low doses, Kratom can produce similar effects to stimulants, which include increased alertness and energy, and a heightened sense of arousal and happiness.1,2 The medicinal use of Kratom in Southeast Asia has a long history, dating back hundreds of years.3
Widespread Kratom use in the United States is relatively new.3 However, in recent years, medical professionals, the U.S. Drug Enforcement Agency (DEA), U.S. Department of Agriculture (USDA), and the U.S. Food and Drug Administration (FDA) have shown concerns about Kratom use.1
Kratom is often used to help alleviate chronic pain and opioid withdrawal symptoms because many people think it’s safer than opioids. However, more extensive research still needs to be done to prove this.1
Partygoers misuse Kratom for its euphoric, relaxing, and stimulating effects. Kratom is often marketed as an appetite suppressant and a remedy for anxiety, depression, and panic attacks.1,3 Kratom use has increased in popularity in Western countries over the past decade; current estimates are that as many as 5 million individuals in the United States use Kratom regularly.3

Kratom is still legal in the U.S., though some countries have banned kratom and kratom products.1 The DEA has classified kratom as a “drug and chemical of concern,” but it is not listed as a controlled substance under the Controlled Substances Act.2,3 Regulations about kratom possession and use may differ by each state.2,3
The DEA proposed assigning kratom as a Schedule 1 controlled substance (the same category as heroin), resulting in the possession of kratom being illegal.3 However, this decision was put on hold due to severe backlash from many consumers in the U.S. who state that kratom has beneficial properties in treating opioid dependence and withdrawal symptoms.3
Kratom and associated kratom products are still considered legal substances and available in many areas, though authorities like the FDA conduct ongoing reviews that help to inform policies regarding kratom.1 The FDA has advised consumers that they should not use kratom or kratom products due to the potential for adverse effects.1
While kratom is not yet fully understood, scientists know that it produces its effects because it contains many different chemical compounds.1 As with any substance, kratom's effects can vary based on several factors, such as how much kratom a person takes, how they take it, if they use it with other substances, and whether they have co-occurring medical or psychological conditions.1
Research is still ongoing about the short- and long-term effects of kratom, so it’s difficult to predict the effects a person might experience, especially since products and formulations can vary widely.1 Additionally, some products contain contaminants like bacteria such as Salmonella, which can result in unwanted and unpredictable effects.1
Kratom can produce opioid and stimulant effects.1 Stimulant effects tend to occur at low doses, and kratom opioid effects (sedative effects) can occur at high doses.3 Some of the stimulant effects of kratom include:1,3
The opioid-like effects of kratom include:1,3
Kratom use is not without potential health risks. Some of the reported adverse effects of kratom include:1,3
There have been reported deaths associated with kratom use, but most of these have occurred because people used kratom with other substances or unknown contaminants in the product.1
Maybe. In terms of addiction, medically known as a substance use disorder (SUD), there is not enough evidence-based research to determine whether kratom is addictive.1
It’s believed that misuse may cause kratom dependence due to its stimulant and opioid-like painkilling effects.4 Dependence occurs over time when a drug is misused to the point that the body believes it needs it to function properly.
As a result of physical dependence, when the dosage is reduced or drug use stops completely, the individual may experience withdrawal symptoms.5 Research is ongoing to investigate kratom withdrawal and addictive potential.1,3,5
Dependence is not always associated with addiction meaning that an individual can be dependent on a substance but not addicted to kratom. The main concerns are the potentially dangerous effects of kratom misuse and the uncomfortable withdrawal symptoms.1
Currently, there is no conclusive evidence on the extent of withdrawal symptoms caused by kratom use.1,3 While research is ongoing, studies suggest that kratom can lead to mild to moderate withdrawal symptoms when a person stops or reduces use.1,3
Quitting kratom “cold turkey” may be uncomfortable, but it does not appear to have any life-threatening side effects associated with its use or its withdrawal syndrome. However, because so little is known about the substance, it’s a good idea to get guidance from your doctor or another medical professional. Medical detox can help ensure your comfort and safety and ease the transition to ongoing treatment, such as an inpatient or outpatient rehab program, which can help you maintain recovery.4
Attempting to quit Kratom on your own can be difficult. Many people use Kratom to help alleviate chronic pain and opioid withdrawal symptoms, which can further complicate quitting. If you’re trying to stop using kratom, you should know that professional help is available and can help manage the discomfort associated with withdrawal from kratom and opioid use disorder (OUD).1

Currently, there is no conclusive evidence on the withdrawal timeline of kratom. The onset of withdrawal and how long kratom withdrawal lasts may mimic that of opioid withdrawal, but more research is needed.5
Some studies suggest withdrawal symptoms may begin around 12 to 24 hours after a person last uses kratom and may last up to four days.6 Several factors can influence withdrawal, including how much kratom a person uses, for how long, and whether they use other substances.6
Kratom withdrawal symptoms may include:7

Although some people can quit taking kratom on their own, professional treatment provides several benefits to facilitate the process. Kratom addiction treatment centers and recovery programs include:8
Kratom misuse can affect both health and quality of life, but recovery is possible with the right support. Find treatment programs near you that offer expert care, evidence-based therapies, and a path toward lasting healing.
National Institute on Drug Abuse. (n.d.). Kratom. https://nida.nih.gov/research-topics/kratom
U.S. Drug Enforcement Administration. (April, 2020). Kratom.
Eastlack, S. C., Cornett, E. M., & Kaye, A. D. (2020). Kratom—Pharmacology, clinical implications, and outlook: a comprehensive review. Pain and therapy, 9(1), 55-69. https://pmc.ncbi.nlm.nih.gov/articles/PMC7203303/pdf/40122_2020_Article_151.pdf
Veltri, C., & Grundmann, O. (2019). Current perspectives on the impact of Kratom use. Substance abuse and rehabilitation, 10, 23–31. https://pmc.ncbi.nlm.nih.gov/articles/PMC6612999/pdf/sar-10-23.pdf
U.S. Drug Enforcement Administration. (2019, November). Kratom (Mitragyna speciosa korth). https://www.deadiversion.usdoj.gov/drug_chem_info/kratom.pdf
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
Stanciu, C. & Penders, T. (2020, October 6). Best practices in managing patients with Kratom addiction. https://pcssnow.org/wp-content/uploads/2020/09/KRATOM-webinar-PCSS-2020-final-version-9.28.20-1.pdf
National Institute on Drug Abuse. (2020, August 20). Commonly used drugs charts: Kratom. https://nida.nih.gov/research-topics/drugs-a-to-z#kratom
National Institute on Drug Abuse. (2017, May). How do medications to treat opioid use disorder work? . https://nida.nih.gov/research-topics/medications-opioid-use-disorder
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