If you’re exploring options for anxiety treatment, you’ve likely heard of Ativan (lorazepam) and Xanax (alprazolam). These medications belong to a group called benzodiazepines, and while they’re similar in many ways, they each have unique characteristics that make them better suited for different situations.
While these medications are related and share many traits, each has its own distinct profile. Understanding the differences between Ativan and Xanax can help you have more productive conversations with your healthcare provider about which option might work best for you.
Both of these medications work with your brain’s natural calming system by enhancing the effects of GABA, a neurochemical that helps reduce anxiety. But they differ in important ways—including how quickly they kick in, how long their effects last, and what they’re typically used for.
One of the main things that sets these medications apart is how long they stay active in your system. Ativan typically works for 6-8 hours,1 making it helpful for people who need steady anxiety relief throughout the day. Think of it like a slow-release capsule that provides consistent support over a longer period.
The effects of Xanax peak at around 1-2 hours2 and last for up to 6 hours. While this shorter duration means you might need to take it more often, it can be helpful for people who need quick relief from sudden anxiety or panic attacks and prefer not to have long-lasting effects.
These medications also differ in how quickly they start working. Xanax typically starts working within 15-30 minutes, making it especially effective for managing unexpected anxiety or panic attacks. It’s like having a rapid-response remedy ready when you need quick relief.
Ativan usually takes 30-60 minutes to kick in. While this slower onset might not be ideal for panic attacks, many people appreciate its more gradual approach. This gentler onset can mean less intense initial effects, which some people find more comfortable.
Doctors prescribe these medications for slightly different purposes, based on how they work in the body and what they’re approved to treat.
Ativan is usually prescribed for:
Xanax is often prescribed for:
Both Ativan and Xanax work by boosting GABA’s effects in the brain. GABA is a brain chemical that reduces neural activity, helping to create a calming effect. However, these medications process through the body differently.
Xanax vs. Ativan effects in the Body
Ativan metabolizes directly into an inactive compound, while Xanax breaks down into several active metabolites3 before your body then eliminates them. This metabolic difference partly explains why Xanax may have more pronounced effects initially but can also cause more complicated withdrawal symptoms.
Both Ativan and Xanax’s side effects4 typically include:
Most people experience mild side effects when they start taking anxiety medications. These usually improve as your body adjusts. If you’re concerned about any effects you’re experiencing, discuss these with your prescribing doctor.
While less common, both medications can potentially cause more serious effects:
People commonly combine benzos with alcohol, either recreationally or to cope with anxiety. This dramatically increases the risk of adverse side effects, addiction, and overdose. Learn more in our article on mixing alcohol and other substances.
While both medications share many similar effects, there are some differences in how people typically experience them:
Ativan often causes:
Xanax typically involves:
It’s important to have an open conversation about the risks associated with these medications. Both Ativan and Xanax can lead to physical dependence, even if you take them exactly as prescribed. This is simply a result of how these medications work in the brain.
When you take benzodiazepines regularly, your brain adjusts to their presence. Over time, you might notice that you need a higher dose to get the same calming effect—this is called tolerance. Some people may become dependent on benzos5 within just a few weeks, which is why healthcare providers typically prescribe these medications for short-term use or as needed.
If you’re experiencing any of the following, it could be a sign that you’re developing a dependency:
If you’ve been taking Xanax or Ativan regularly, you should not stop taking it suddenly. Always work with your healthcare provider to create a safe tapering plan. Withdrawal symptoms can be uncomfortable—and potentially dangerous—if they’re not managed properly.
Common withdrawal experiences include:
Xanax’s shorter half-life6 means withdrawal symptoms might appear more quickly and feel more intense. Ativan’s longer-acting nature usually means a more gradual withdrawal experience.
Using these medications safely means taking them exactly as prescribed and avoiding alcohol and other sedating substances while taking them. That said, it’s also crucial to be honest with your healthcare provider about any other substances you’re using. Keep attending your regularly scheduled medication management appointments to monitor your progress. And of course, store your medications securely and never share your prescription with others.
When deciding between Ativan vs. Xanax for anxiety, there’s no one-size-fits-all answer. Think of these medications like different tools in a toolbox—each has its ideal use. Your prescriber will consider several factors to determine which might work better for you.
Type of Anxiety
Ativan might be your better option if you have persistent, daily anxiety that needs consistent management. If you deal with panic attacks or sudden anxiety spikes, Xanax could be more suitable.
Lifestyle Considerations
Which anxiety medication is best for you also depends on your:
Personal Factors
Other factors can also affect your treatment plan:
Doctor’s Recommendation
Your healthcare provider brings valuable expertise to this decision. They’ll consider:
Keep an open line of communication with your doctor about your concerns and preferences. This will help them make the best recommendation for your situation.
While benzodiazepines are helpful for a lot of people, they’re not the only option for managing anxiety. There are many effective alternatives, both in terms of other medications and non-medication approaches.
Several other types of medications can help manage anxiety symptoms:
SSRIs and SNRIs
These medications (like Zoloft, Lexapro, or Effexor) work differently from benzodiazepines. Instead of providing immediate relief, they help regulate brain chemistry over time. They’re typically used to treat depression, but many people find them effective for long-term anxiety management without the risk of dependence.
Beta Blockers
These medications primarily help with the physical symptoms of anxiety, like racing heart and trembling. They’re usually used for specific situations like public speaking or performances.
Buspirone
This medication specifically treats anxiety without causing significant sedation or dependency.7 It works well for many people, though it typically takes a few weeks to feel the full effects.
Medication isn’t the only way to manage anxiety. Many people find these approaches helpful, either on their own or alongside medication:
Cognitive Behavioral Therapy (CBT) and Other Talk Therapies
CBT helps you understand and change thought patterns that contribute to anxiety. It’s like learning a new language—at first it takes conscious effort, but it becomes more natural with practice. Research shows CBT can be just as effective as medication for anxiety. According to the American Psychological Association,
For anxiety disorders, cognitive-behavioral therapy, antidepressant medications and anti-anxiety medications have all been shown to be helpful. Research generally shows that psychotherapy is more effective than medications, and that adding medications does not significantly improve outcomes from psychotherapy alone.
Mindfulness and Meditation
Mindfulness is the practice of staying grounded in the present moment. Many people find this helps ease their anxiety, as the brain tends to get caught up in anxiety about the future. Significant scientific evidence supports this. A study of 187 adults seeking treatment for mood and anxiety disorders found that mindfulness helps reduce anxiety by reducing worry.8 Even a few minutes of daily mindfulness can make a noticeable difference in managing anxiety symptoms.
Exercise and Lifestyle Changes
Getting daily physical activity, maintaining good sleep hygiene, and learning techniques for managing stress can help lower your anxiety levels. Some people find that making these changes reduces or even completely eliminates their need for anxiety medication.
Remember, seeking help for anxiety is a sign of strength, not weakness. Whether you’re considering starting one of these medications, currently taking them, or looking for alternatives, your healthcare provider can discuss your options and create a treatment plan that’s personalized to your needs.
Working with your treatment team to find the right approach—whether that includes Ativan, Xanax, other medications, or non-medication alternatives—is an important step in managing anxiety and improving your quality of life. Don’t hesitate to ask questions and share your concerns as you work together to find the best solution for your specific situation.
If you’re looking for a strong start to your anxiety healing journey, anxiety treatment programs offer comprehensive treatment in an immersive, recovery-focused setting. Search for an anxiety treatment center that fits your needs and speak directly with an admissions specialist today.
No, healthcare providers don’t prescribe these medications together because they work in very similar ways. Taking both could increase the risk of side effects without providing additional benefits.
Most healthcare providers recommend using benzodiazepines for short periods (a few weeks to months) or as needed for specific situations. Long-term use should be carefully monitored by your healthcare provider.
Yes, many alternatives exist, including SSRIs, SNRIs, buspirone, and various non-medication treatments like therapy and mindfulness practices. Work with your healthcare provider to find the best option for your situation.
Always work with your healthcare provider to create a tapering plan. Never stop taking these medications suddenly, as this can lead to withdrawal symptoms that can range from uncomfortable to very dangerous.
Until you know how either medication affects you, avoid driving or operating machinery. Some people experience significant drowsiness or decreased coordination, especially when first starting the medication or after dose changes.
Lorazepam - an Overview | ScienceDirect Topics. https://www.sciencedirect.com/topics/neuroscience/lorazepam. Accessed 25 Jan. 2025.
George TT, Tripp J. Alprazolam. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538165/
Daniel J. Carlat, MD. “Drug Metabolism in Psychiatry A Clinical Guide.” The Carlat Psychiatry Report. https://www.thecarlatreport.com/ext/resources/2022/11/02/Carlat-Drug-Metabolism-in-Psychiatry-2015.pdf
Bounds CG, Patel P. Benzodiazepines. [Updated 2024 Jan 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470159/
Benzodiazepine Dependence - an Overview | ScienceDirect Topics. https://www.sciencedirect.com/topics/medicine-and-dentistry/benzodiazepine-dependence. Accessed 25 Jan. 2025.
George TT, Tripp J. Alprazolam. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK538165/
Buspirone: MedlinePlus Drug Information. https://medlineplus.gov/druginfo/meds/a688005.html. Accessed 25 Jan. 2025.
Desrosiers, Alethea, et al. “MINDFULNESS AND EMOTION REGULATION IN DEPRESSION AND ANXIETY: COMMON AND DISTINCT MECHANISMS OF ACTION: Research Article: Mindfulness and Emotion Regulation.” Depression and Anxiety, vol. 30, no. 7, July 2013, pp. 654–61. DOI.org (Crossref), https://doi.org/10.1002/da.22124.
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