


Dr. Bapat is a licensed psychologist. Her clinical work has included treatment in outpatient and residential rehab settings for varied mental health conditions such as mood disorders, generalized anxiety, PTSD, and substance use disorders.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.




Dr. Bapat is a licensed psychologist. Her clinical work has included treatment in outpatient and residential rehab settings for varied mental health conditions such as mood disorders, generalized anxiety, PTSD, and substance use disorders.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.
The use of more than one substance, or “polysubstance use”, can be unpredictable, dangerous, and potentially deadly.1 As a result, people who simultaneously misuse multiple substances run the risk of experiencing several negative outcomes.
This page will focus on the effects and dangers of polysubstance use involving alcohol and methamphetamine, including what potential interactions may occur, risk of addiction, and how to seek treatment.
Of the 2 million Americans who reported using meth in the past year, 13.4% (268,000 people) also reported heavy alcohol use.2 However, consuming alcohol while using drugs like meth (or vice versa), is never safe.1 Despite any misconceptions, using a depressant like alcohol and a stimulant like meth at the same time does not balance out their effects.1 Instead, doing so can modify and even mask the effects of one or both substances, which can make it easier for an overdose to occur.1
The effects of combining alcohol and meth can depend on certain factors, such as gender, age, how much of each substance was consumed, and how they were administered.3
Alcohol is a CNS depressant, meaning that it slows down brain function and neural activity.1 At first, this causes feelings of euphoria and relaxation, but when consumed in larger amounts, it can result in a number of short-term effects.
Short-term effects like these can also lead to additional risks, such as engaging in risky behaviors like unprotected sex or causing or sustaining injuries.6
The continued, chronic misuse of alcohol has its risks, too. These effects can be dangerous and cause problems that last long after alcohol is no longer being consumed.
Methamphetamine is a highly addictive and illegal stimulant that is made in homemade labs from a mixture of dangerous chemicals.7 Stimulants are known to speed up the central nervous system, meaning they cause symptoms like increased respiratory rates, increased heart rates, and a rise in blood pressure.7 Unlike amphetamines, which are legal prescription stimulants used to treat medical disorders such as ADHD, methamphetamines, although structurally similar to amphetamine, have no medicinal purpose and a very high addiction potential.7
The terms “meth” and “crystal meth” are often used interchangeably, however, they are not the same.7 Meth comes in powder form, while crystal meth comes in solid, crystalline form that is “glass” like in appearance.7 Although they are structurally and chemically similar, crystal meth is purer and therefore more potent compared to meth. Additionally, meth is often snorted, injected, or swallowed whereas crystal meth is usually smoked or injected, resulting in a faster and more powerful “high”.7
Continued use of meth can cause even more health effects, some of which may be far more serious in nature.
When alcohol and meth are being misused simultaneously, several interactions can occur.8 For example, research indicates that alcohol may slow down how meth is metabolized, or processed, in the body, meaning that it can increase the concentration of meth in the bloodstream, elevating one’s overall risk of toxicity.8
Consuming alcohol with stimulants like meth can also cause interactions that compromise the functioning of the cardiovascular system, such as increased heart rate, elevated blood pressure, and decreased blood flow to the heart.8
Using both alcohol and meth can increase the likelihood of an overdose, which can be fatal.1 Since alcohol is a depressant and meth is a stimulant, both of these substances can mask each other’s desired effects, often causing a person consume more in order to achieve the desired effects.1 This can lead to high levels of alcohol and/or meth consumption, making it easier to overdose.1
If someone you know or love is experiencing an overdose, call 911 right away.1 Try to keep the person awake and wait with them until help arrives.1
Effective addiction treatment is available and can help address polysubstance use disorders like those that involve alcohol and meth. If you are in need of professional care, know that there are a variety of different levels of treatment that can meet you where you are at in your addiction. These typically include:9
If you or a loved one is ready to seek rehab for a substance use disorder, explore your options and reach out to a rehab center using our rehab directory tool today!
Substance Abuse and Mental Health Services Administration. (2024). Key Substance Use and Mental Health Indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP24-07-021, NSDUH Series H-59). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration. https://www.samhsa.gov/data/sites/default/files/reports/rpt47095/National%20Report/National%20Report/2023-nsduh-annual-national.pdf
National Institute on Alcohol Abuse and Alcoholism. (2024). Understanding the Dangers of Alcohol Overdose. https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/understanding-dangers-of-alcohol-overdose
National Institute on Alcohol Abuse and Alcoholism. (n.d.). Alcohol’s Effects on the Body. https://www.niaaa.nih.gov/alcohols-effects-health/alcohols-effects-body
Centers for Disease Control and Prevention. (2025, January 14). Alcohol Use and Your Health. https://www.cdc.gov/alcohol/about-alcohol-use/index.html
National Institutes of Health. (2019). Methamphetamine. https://nida.nih.gov/publications/research-reports/methamphetamine/what-methamphetamine
Singh, A.K. (2019, March 7). Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid. Biomedicines, 7(1),16. https://pmc.ncbi.nlm.nih.gov/articles/PMC6466217/
Center for Substance Abuse Treatment. (2004). What is Substance Abuse Treatment? A Booklet for Families. HHS Publication No. (SMA) 14-4126. Rockville, MD: Substance Abuse and Mental Health Services Administration. https://store.samhsa.gov/sites/default/files/d7/priv/sma14-4126.pdf
We believe everyone deserves access to accurate, unbiased information about mental health and recovery. That’s why we have a comprehensive set of treatment providers and don't charge for inclusion. Any center that meets our criteria can list for free. We do not and have never accepted fees for referring someone to a particular center. Providers who advertise with us must be verified by our Research Team and we clearly mark their status as advertisers.
Our goal is to help you choose the best path for your recovery. That begins with information you can trust.