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Dr. Scot Thomas received his medical degree from the University of California, San Diego School of Medicine. During his medical studies, Dr. Thomas saw firsthand the multitude of lives impacted by struggles with substance abuse and addiction, motivating him to seek a clinical psychiatry preceptorship at the San Diego VA Hospital’s Inpatient Alcohol and Drug Treatment Program.




The editorial staff of Recovery.com is comprised of addiction content experts. Our editors and medical reviewers have over a decade of cumulative experience in medical content editing and have reviewed thousands of pages for accuracy and relevance.

Dr. Scot Thomas received his medical degree from the University of California, San Diego School of Medicine. During his medical studies, Dr. Thomas saw firsthand the multitude of lives impacted by struggles with substance abuse and addiction, motivating him to seek a clinical psychiatry preceptorship at the San Diego VA Hospital’s Inpatient Alcohol and Drug Treatment Program.
Lysergic acid diethylamide, also known as LSD, is a hallucinogenic drug best known for its ability to produce altered mental states, visual hallucinations, and synesthesia, or the experience that senses are being crossed over—for instance, hearing colors or seeing sounds. Pure forms of LSD occur as a clear or white crystalline substance when stored at room temperature. LSD can be sold in tablet form, or infused onto sugar cubes, thin squares of gelatin, or blotter paper for oral consumption.
LSD is believed to affect 2 neurotransmitters: serotonin and glutamate.
It is unclear how LSD produces its effects. But it is believed to affect 2 neurotransmitters in the brain.
A popular theory is that it acts as a serotonin receptor agonist, which leads to increased levels of this neurotransmitter in the brain.2 Serotonin affects mood, appetite, sexual functioning and sleep cycle.
LSD is also believed to initiate a cascade of signaling events that influences glutamate activity throughout the brain. Glutamate is an excitatory neurotransmitter that plays a role in cognition, memory and learning.6
Additionally, in concert with serotonin, glutamate activity helps to mediate the brain’s response to a variety of sensory stimuli and is thought to play a role in the mechanism underlying the intense hallucinations of LSD.
The cost of an LSD recovery program will depend on:
Below are options for how to find a rehab center with or without insurance.
Find out more about how to choose a rehab program for LSD abuse.
As a recreational drug, LSD has the potential to produce very intense experiences. Some short-term effects include:
The side effects of taking LSD include:
Two long-term effects have been found in people who abuse LSD:
Neither of these conditions is common. They are more likely to occur in people who have a history of psychological issues. But they can happen to anyone and even happen after taking the drug once.
LSD is not considered a physically addictive drug, and its toxicity is relatively low. It is not available by prescription, and it is illegal to use or possess LSD. Unlike alcohol, cocaine, or heroin, LSD does not lead to compulsive drug-seeking behavior.
Although LSD is not thought to be physically addictive, some users develop hallucinogen use disorder. This condition is characterized by a problematic pattern of use that significantly impairs a user’s life. 7
That said, hallucinogen use disorder is one of the rarest substance use disorders. Within the mental health community, there are not confirmed withdrawal symptoms associated with LSD. Regular users do develop tolerance with repeated abuse, though.
It is difficult to overdose on LSD, and no deaths have been reported from overdose.
The 2014 National Survey on Drug Use and Health found the following rates of current LSD use. These rates appear to be relatively stable since 2002.
The 2014 Monitoring the Future Study, a yearly survey of teen drug use, found the following percentages of teens had used LSD at least once in their lives:
These rates represent a slight decrease from 2013 and continue a downward trend since 2011.
If LSD use has become a problem for you or someone you love, reach out to a treatment center today.
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