ONCE Center
ONCE Center
ONCE Center
About ONCE Center
A legal, medically supervised psilocybin-assisted mental health center in Amsterdam, ONCE supports adults facing burnout, chronic stress, exhaustion, depression, and anxiety. Co-founded by psychiatrist and neuroscientist Alexander Lebedev, MD, PhD, the center translates decades of global research and FDA-recognized breakthrough science into a structured, evidence-based program. It's designed for people with full lives, with most of the process delivered online and only 1 day required on-site.
Fit Treatment Around a Busy Life
The program typically runs 4 to 6 weeks along a clear, personalized path. It begins with a free initial conversation and a medical screening with a licensed physician, followed by online preparation sessions using the evidence-based Internal Family Systems (IFS) approach. Clients then travel to Amsterdam for a single full-day psilocybin session guided by a familiar facilitator, before finishing with a recovery day and online integration sessions that turn insights into lasting change.