


Hannah is a licensed master social worker and obtained her master's degree in social work from the University of Georgia. She currently works as a therapist with a focus on clients who have ADHD and anxiety. She has experience leading groups and working with people who are struggling with addiction and homelessness.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.




Hannah is a licensed master social worker and obtained her master's degree in social work from the University of Georgia. She currently works as a therapist with a focus on clients who have ADHD and anxiety. She has experience leading groups and working with people who are struggling with addiction and homelessness.

Kristen Fuller, M.D., enjoys writing about evidence-based topics in the cutting-edge world of mental health and addiction medicine and contributes to medicine board education.
Antisocial personality disorder (APD) is a type of severe mental health disorder that has a strong correlation with substance misuse and co-occurring disorders. A co-occurring disorder is a term used to describe a substance use disorder (SUD) and a mental health disorder that is occurring at the same time.1
Continue reading to learn about what antisocial personality disorder is, potential causes, the signs of antisocial personality disorder, and the relationship between antisocial personality disorder and addiction.
Antisocial personality disorder is classified as a cluster B type personality disorder in the Diagnostic and statistical manual of mental disorders, 5th Edition (DSM 5), in which people have emotional and unpredictable behavior when interacting with other people.2 It is characterized by highly dysfunctional thought processes and deceitful, manipulative behaviors that show disregard and lack of empathy for others.2,3,4
Antisocial personality disorder can sometimes be confused with:4
APD is correlated with a high rate of substance misuse.2,4 People who have co-occurring APD and a substance use disorder are also more likely to begin using substances at earlier ages, which can make rehabilitation a more challenging process.5
The exact cause of antisocial personality disorder isn’t known, but research suggests it occurs due to a combination of genetic and environmental factors, including:2
Specifically, childhood trauma survivors show a significant risk of developing co-occurring disorders.1 The development is thought to correlate to attempts to self-medicate from the trauma or to manage post-traumatic stress symptoms.1
Only a trained mental health professional can diagnose antisocial personality disorder, other mental health disorders, and substance use disorders. A mental healthcare practitioner can identify symptoms and prescribe appropriate treatment, which may include medication, and refer to a medical doctor for additional physical concerns.3
Criteria for being diagnosed with antisocial personality disorder include the following:4
All other disorders should be ruled out through a careful physical examination and history intake before diagnosing antisocial personality disorder to ensure a person receives proper care and treatment.3
Personality disorder diagnoses, like antisocial personality disorder, range from 34.8% to 78% among people who are diagnosed with an addiction.5 Antisocial personality disorder and borderline personality disorder are among the top 2 personality disorders ranked for prevalence among people diagnosed with a substance use disorder.5
Studies show that antisocial personality disorder and substance misuse are often influenced by trauma.2 Overlapping causes for co-occurring substance use and mental health disorders include stress, epigenetics, brain changes, and adverse childhood experiences.1
Additionally, researchers believe that antisocial personality and substance use disorders are commonly diagnosed together because of impulsive and aggressive tendencies.6 Both disorders affect the same part of the brain, leading to an increased risk of aggression and impulsivity.6
Antisocial personality disorder and borderline personality disorder are among the top 2 personality disorders ranked for prevalence among people diagnosed with a substance use disorder.5
Alcohol, cannabis, and nicotine use disorders are most commonly diagnosed in people with antisocial personality disorder.6 There’s an increase in the chances of a person receiving an antisocial personality disorder diagnosis if they have long-term drug use that exceeds 12 months.7
A pattern of polysubstance misuse can also be observed in those who have antisocial personality disorder and who misuse substances.7 This may be attributed to what’s available to the person at the time of use. As teenagers and children are developing, substances can have a greater impact on their brain functioning, resulting in more severe mental illness and substance use disorder symptoms.1
Alternatively, having a mental illness in childhood increases the odds that a person will be diagnosed with a substance use disorder.1 Better diagnosis methods and identification can help bridge this gap in care that can later lead to co-occurring disorders.1
Individualized treatment is important when treating mental health and substance use disorders to ensure each person gets the appropriate level of care and support necessary to help them recover.8
The following are different types of treatment used for co-occurring antisocial personality disorder and substance use disorder:5
Unfortunately, there aren’t many studies available that report on effective treatment for co-occurring antisocial personality disorder and substance use disorder.2 This is due to a multitude of challenges that people face when getting treatment.
The following are common challenges a practitioner may encounter when treating a person with antisocial personality disorder and substance use disorder together:2
Living with or supporting a person with co-occurring disorders can be challenging; however, with support, you or a loved one may find the help they need to stop using substances and start on a new path.
If you or a loved one is ready to seek rehab for a substance use disorder, explore your options and reach out to a rehab center using our rehab directory tool today!
National Institute on Drug Abuse. (2018, August 1). Comorbidity: Substance Use Disorders and Other Mental Illnesses DrugFacts. https://nida.nih.gov/publications/drugfacts/comorbidity-substance-use-disorders-other-mental-illnesses
Fisher, K.A. & Hany, M. (2022, May 15). Antisocial Personality Disorder. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. https://www.ncbi.nlm.nih.gov/books/NBK546673/
American Psychiatric Association. (2018, November). What are personality disorders?. https://web.archive.org/web/20230128192342/https://www.psychiatry.org/patients-families/personality-disorders/what-are-personality-disorders
Parmar, A. & Kaloiya, G. (2018, November-December). Comorbidity of personality disorder among substance use disorder patients: A narrative review. Indian J Psychol Med. 40(6). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241194/
Substance Abuse and Mental Health Services Administration. (2020). Substance Use Disorder Treatment for People With Co-Occurring Disorders. https://store.samhsa.gov/sites/default/files/SAMHSA_Digital_Download/PEP20-02-01-004_Final_508.pdf
National Institute on Drug Abuse. (2020, September 18). Principles of Effective Treatment. https://www.ncbi.nlm.nih.gov/books/NBK424859/table/ch4.t2/
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